@article{Chernatska_Demikhova_2018, title={Structural, functional and endothelial peculiarities of diabetic nephropathy in patients with arterial hypertension}, url={https://ukrjnd.com.ua/index.php/journal/article/view/251}, DOI={10.31450/ukrjnd.2(58).2018.03}, abstractNote={<p>The aim of our one-stage observational study was the detail analysis of structural, functional, endothelial peculiarities of diabetic nephropathy in patients with coexistent arterial hypertension.</p> <p>Methods. Our study involved 96people with arterial hypertension and type 2 diabetes mellitus (I group), 25 patients with arterial hypertension (II group), 15 practically healthy persons (III group) treated and obtained in Sumy City Clinical Hospital №1. Cardiovascular complications were determined in all patients from I and II groups. The average age of the patients was 62.31 ± 0.2 years. The level of glycosylated hemoglobin (HbAlc) was determined by the biochemical method, albuminuria by immunoassay. The level of endothelin-1 (ET-1) in serum was studied using ELISA.</p> <p>Results. It was found that the level of ET-1 was significantly higher in patients with diabetes compared with only hypertensive patients. In the patients with urine albumin excretion rate category A2 the level of endothelin-1 was significantly higher compared with the category A1 patients and less compared with category A3 patients (11.42 ± 49 vs 25 ± 0.57pg/ml, p = 0.0329 and 11.42 ± 0.49 vs 2.25 ± 1.04pg/ml, p &lt;0.0001, respectively. So, the level of ET-1 increased in proportion to albuminuria. In patients with the albuminuria category A2, the endothelin-1 level was higher than in subjects with the A1 category and lower than in patients with the A3 category. In addition, we identified a moderate direct correlation between the blood level of ET-1 in the patients with diabetes and blood glucose level (r = 0.29;p = 0.004).</p> <p>Conclusion. Finally, it is the confirmation of greater endothelial function disorders for arterial hypertension and type 2 diabetes mellitus. In conclusion, endothelial dysfunction promotes diabetic nephropathy progression.</p&gt;}, number={2(58)}, journal={Ukrainian Journal of Nephrology and Dialysis}, author={ChernatskaО. M. and Demikhova, N. V.}, year={2018}, month={May}, pages={13-17} }