INTERLEUKIN 10, BODY MASS INDEX AND SERUM ALBUMIN IN CHRONIC KIDNEY DISEASE STAGE 5D PATIENTS

  • I. Dudar
  • V. Drijanska
  • E. Grigorjeva
  • J. Gonchar
  • E. Krasjuk
Keywords: haemodialysis, inflammation, nutrition, interleukin, IL-10, albumin

Abstract

IL-10 - one of the central factors in the altered cytokine network of uremia, may play important role in the development of T-helper imbalance, CVD and wasting in dialysis patients.

Aim: to evaluate level of ІL-10 in CKD stage 5D patients depending on the body mass index and serum albumin.

Methods: Thirty-nine HD patients were included (male/female 20/19, age 21- 53 years, mean dialysis treatment time 4.2 ± 1.21 years). Blood tests were taken before a midweek dialysis session. Serum IL-10, serum albumin and BMI were measured.

Results: HD patients had higher serum IL-10 than healthy donors (79.9 ± 7.3 vs. 18.8 ± 1.3 pg/ml, p < 0.001). Patients with low BMI had lower serum IL-10 than patients with normal BMI and large BMI – 31.0 ± 6.3 pg/ml; 76.7 ± 10.1 pg/ml; 117.7 ± 6.2 pg/ml, respectively (p < 0.001). Higher IL-10 was associated with increased serum albumin.

Conclusion: Compensative increase of anti-inflammatory cytokine IL-10 in serum is typical in HD patients. Patients with nutrition deficit are characterized by lower serum IL-10.

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References

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Abstract views: 503
PDF Downloads: 175
Published
2017-12-12
How to Cite
Dudar, I., Drijanska, V., Grigorjeva, E., Gonchar, J., & Krasjuk, E. (2017). INTERLEUKIN 10, BODY MASS INDEX AND SERUM ALBUMIN IN CHRONIC KIDNEY DISEASE STAGE 5D PATIENTS. Ukrainian Journal of Nephrology and Dialysis, (4(40), 30-33. https://doi.org/10.31450/ukrjnd.4(40).2013.04

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