HLA-PHENOTYPE IN PATIENTS WITH GLOMERULONEPHRITIS WITH VARIOUS MORPHOLOGIC FORMS AND NEPHROTIC SYNDROM
Abstract
In the work was determined the HLA-phenotype specificities in patients with different morphologic forms of chronic glomerulonephritis and nephrotic syndrome (CGN, NS) to define the additional predictors of a disease course.
Materials and methods. There was studied the HLA-antigens distribution in the 264 CGN, NS patients and 350 healthy donors by typing the lymphocytes with the aid ofstandard microlymphocytotoxic test (Terasaki’s test). The diagnosis was confirmed morphologically using the thin needle nephrobiopsy.
Results. It is advisable to associate CGN, NS (RR > 2) with antigens HLA- A23, 24, 28; B8, 38, 41, 44 in patients; the causal role (a > 0.1) was determined for A24, 28; B8. In proliferative GN was additionally revealed the etiologic role of B27 known as antigen associated with risk ofautoimmune diseases. In patients with various morphologic forms is advisable the association of some antigens with development of chronic renal failure (CRF) – A30, B41 in FSGS, A10 – MGN; and also hormone resistance (HR) – A19+31+32 in FSGS, B8 – MGN and MC.
Conclusion. The revealed reliable associations ofHLA types both with CGN, NS and its separate morphologic forms with the risk of CRF and/or HR allow take into consideration the availability ofsuch antigens in phenotype ofpatients with confirmed by biopsy diagnosis as the additional diagnostic and prognostic markers.
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Дранник Г. Н. Клиническая иммунология и аллергология / Г. Н. Дранник. – К. : ООО «Полиграф Плюс» - Киев, 2011 р. - 560 с.
Зарецкая Ю. М. Клическая иммуногенетика / Ю.М Зарецкая. - М. : Медицина, 1983. – 208 с.
Колесник М. О. HLA-фенотип у хворих на хронічний гломерулонефрит з нефротичним синдромом / М. О. Колесник [та ін.] // Журнал НАМН України. - 2014. - Т. 20, № 2. - С. 206-211.
Корякова Н. Н. Патогенетические особенности различных клинико-морфологических вариантов хронического гломерулонефрита / Н. Н. Корякова // Нефрология. - 2005. - Т. 9, № 1. - С. 58-62.
Al-Elise A. A. HLA DR alleles in Kuwaiti children with idiopathic nephritic syndrome / A. A. Al-Elise // Ped. Nephrol. - 2000. - 15 (1-2). - Р. 79-81.
Clark A. G. B. Genes encoding the be chains of HLA DR7 and HLA DQw2 define major susceptibily de- merminants for idiopatic NC / A. G. B. Clark [et al.] // Clin. Sci. - 1990. - 78. - Р. 391-397.
Fogo A. B. Nephrotic syndrome: Molecular and genetic basis / A. B. Fogo // Nephron. – 2000. – Vol. 85, № 1. - P. 8-13.
Krensky Alan M. Molekular Biology of Transplantation / Alan M. Krensky // Nephron. – 2000. – 86. – Р. 260-265.
Lechler R. HLA and disease / R. Lechler. - London, Academic press limited, 1994. – 186 p.
Levey A. S. Chronic kidney disease as a global public health problem: Approaches and initiatives – a position statement from Kidney Disease Improving Global Outcomes / A. S. Levey, R. Atkins, J. Coresh [et al.] // Kidney International. – 2007. – V. 72. – P. 247-259.
Noss G. Association of minimal change NS with HLA B8 and B13-Clin / G. Noss [et al.] // Nephron. – 1981. – 15. – Р. 172-174.
Park Cheol Whee. Urinary Soluble HLA Class 1 Antigen in Patients with Minimal Change Disease : A Predictor of Steroid Response / Cheol Whee Park [et al.] // Nephron/ - 1998. – 79. - Р. 44-49.
Rashid H. U. The association of HLA and other genetic marckers with glomerulonephritis / H. U. Rashid, S. S. Papiha, B. Agroyannis et al. // Hum Genet. – 1983. – 63. – P. 38-44.
