PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORS

  • О. Chub Kharkiv Medical Academy of Postgraduate Education
  • O. Bilchenko Kharkiv Medical Academy of Postgraduate Education
Keywords: chronic pyelonephritis, antibiotics, resistance, risk factors, plasmids.

Abstract

The aim of the study is to determine the prevalence of plasmid-mediated resistance genes among uro- pathogens from hospitalized patients with chronic pyelonephritis.

Methods. A cross-sectional study of 105patients with chronic pyelonephritis and different stage of chronic kidney disease, was carried. Screening for the presence ofplasmid-mediated genes was performed by polymerase chain reaction. Determining the risk factors was performed by analysis of prevalence Odd-ratio.

Results. The prevalence of plasmid-mediated resistance mechanisms among uropathogens is 36.7%, mainly due to extended-spectrum p-lactamase (25%). The main factors related with appearance of plasmid-mediated resistance genes were age range above 55 years (OR 3.05), hypertension (OR 2.57), Chronic Kidney Disease stage ІІІ (OR 2,03) and V (OR 1,1), in-patient treatment history (OR 2.02), duration of CP more than 10 years (OR 1,97), history of using antibiotics last year (OR 1,41).

Conclusion. Isolation and detection of plasmid-mediated resistance mechanisms among urinary strains are essential for the selection of the most effective antibiotic for the empiric treatment.

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Published
2016-06-03
How to Cite
ChubО., & Bilchenko, O. (2016). PLASMID-INDUCED ANTIBIOTIC RESISTANCE AMONG PATHOGENS OF CHRONIC PYELONEPHRITIS: PREVALENCE OF GENES AND MAJOR RISK FACTORS. Ukrainian Journal of Nephrology and Dialysis, (2(50), 52-55. https://doi.org/10.31450/ukrjnd.2(50).2016.04