PREDICTION OF UNFAVORABLE COURSE OF NEPHROTIC SYNDROME IN CHILDREN: THE MULTIMARKER PARALLEL CASCADE SYSTEM

S. Fomina

doi:10.31450/ukrjnd.3(51).2016.06

S. Fomina State Institution “Institute of nephrology of NAMS of Ukraine”

DOI: https://doi.org/10.31450/ukrjnd.3(51).2016.06

Keywords: Renoscintigraphy, Indirect Renangiography, urine N-Acethyl-β-D-Glucosaminidase, urine fi-Galactosidase, Prognosis, Likelihood Ratio.

Abstract

The aim of study was to investigate the possibility of using the results of different diagnostic tests in children with nephrotic syndrome (NS) asprognostic markers during disease course.

Materials and methods. The operating characteristics of values derived in dynamic renoscintigraphy and indirect renangiography with 99mTc-DTPA, static renoscintigraphy with 99mTc-phosphate, levels of urine renospecific enzymes (N-acethyl-$-D-glucosaminidase and $-galactosidase) were estimated in 480NS children depending on disease activity.

Results. Different levels of prognostic valuefor studiedparameters were confirmed depend ofNS outcome.

Conclusion. Renoscintigraphy indexes and urine renospecific enzymes activity levels should be used as markers of the progression in NS children with the glance to optimal terms of studies' conduction and range parameters. The multimarker parallel cascade Systemfor prediction of unfavorable NS course has been initiated. This System can be regarded as the start ofa new strategic goalfordetermination ofrelevant unfavorable disease courseparameters in any branch ofmedicine.

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References

Березин A. E. Клиническое и прогностическое значение биологических маркеров в стратификации пациентов с кардиоваскулярными заболеваниями (обзор литературы) / А. Е. Березин // Укр. мед. часопис. – 2010. - № 6 (80). С. 79– 85.

Фомша С. П. 1мунотропна терап1я дггей, хворих на гломерулонефрит з нефротичним синдромом: автор. ... доктора мед. наук : 14.01.37 / С. П. Фомша. – К., 2013. - 36 с.

Фомта С. П. Маркери прогресування нефро- тичного синдромому у дггей / С. П. Фомша // Пед1атр1я, акушерство та пнеколопя. – 2012. - № 6. - С. 22-25.

Фоміна С. П. Прогнозування несприятливого перебігу гломерулонефриту з нефротичним синдромом у дітей: ензимуричні маркери / С. П. Фоміна, І. В. Багдасарова, Л. Я. Мигаль // Український журнал нефрології та діалізу. – 2013.-№4.-С. 14-19.

Фомина С. П. Радионуклидные маркеры прогрессирования гломерулонефрита с нефротическим синдромом у детей / С. П. Фомина // Международный журнал педиатрии, акушерства и гинекологии. – 2012. -№3, – С. 12-16.

Harmon W. Е. Glomerular filtration rate in children with chronic kidney disease / W. E. Harmon // Clin. Chem. - 2009. - Vol. 55.-P. 400-401.

KT Clearinghouse [Електронний ресурс] / Canadian institute of health research, Centre for evidence-based medicine. Toronto, 2000-2011. – Режим доступу: http://ktclearinghouse.ca/cebm/practise/ca/

KDIGO Clinical practice guideline for glomerulonephritis // Kidney international supplements. – 2012. - Vol. 2 (S. 2). - P. 139-274.

Lemley К. V. An introduction to biomarkers: applications to chronic kidney disease / К. V. Lemley Ц Pediatr. Nephrol. - 2007. - Vol. 22. - P. 1849– 1859.

Tesch G. H. Review: serum and urine biomarkers of kidney disease: a pathophysiological perspective / G. H. Tesch Ц Nephrology. - 2010. - Vol. 15. - P. 609-616.