RELATIONSHIP OF THE CONDITION OF THE MYOCARDIUM WITH INFRINGEMENTS THE CALCIUM AND PHOSPHORUS METABOLISM INPATIENTS WITH DIABETIC NEPHROPATHY

  • I.I. Topchii GI «National institute of Therapy named after L. Malaya of NAMS of Ukraine»
  • V.P. Denisenko GI «National institute of Therapy named after L. Malaya of NAMS of Ukraine»
  • O.M. Kirienko GI «National institute of Therapy named after L. Malaya of NAMS of Ukraine».
  • P.S. Semenovykh GI «National institute of Therapy named after L. Malaya of NAMS of Ukraine».
  • Yu.S. Yakimenko GI «National institute of Therapy named after L. Malaya of NAMS of Ukraine».
  • V.V. Mazii GI «National institute of Therapy named after L. Malaya of NAMS of Ukraine»
  • O.M. Schenyavskaya ДУ «Національний інститут терапії ім. Л.Т.Малої НАМН України»
Keywords: diabetic nephropathy, myocardium, phosphorus-calcium metabolism.

Abstract

Objective: To establish the possible relationship between changes in cardiac hemodynamics and im-paired phosphate-calcium metabolism and content FGF 23.

Patients and Methods: 260 people with diabetic nephropathy, 64 people with hypertension and 20 healthy individu-als were surveyed. Studied the state of the myocardium and cardiac hemodynamics, blood levels of calcium, phosphorus and FGF 23.

Results and conclusions: between the state of myocardium, cardiac hemodynamics and content FGF23, phos-phorus and calcium are closely interrelated, which is likely mediated through specific receptor apparatus of myocardium and through immunoinflammatory mechanisms. However, the specific mechanisms of action system FGF23 / phosphorus-calcium exchange for anatomical and functional myocardial changes require further investigation.

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References

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Abstract views: 342
PDF Downloads: 275
Published
2017-04-25
How to Cite
Topchii, I., Denisenko, V., Kirienko, O., Semenovykh, P., Yakimenko, Y., Mazii, V., & Schenyavskaya, O. (2017). RELATIONSHIP OF THE CONDITION OF THE MYOCARDIUM WITH INFRINGEMENTS THE CALCIUM AND PHOSPHORUS METABOLISM INPATIENTS WITH DIABETIC NEPHROPATHY. Ukrainian Journal of Nephrology and Dialysis, (2(54), 27-32. https://doi.org/10.31450/ukrjnd.2(54).2017.06