The level of chorionic gonadotropin in postmenopausal women with CKD V stage treated with hemodialysis

  • K. Abrahamovych Danylo Halytsky Lviv national medical university
  • I. Dudar SI «Institute of Nephrology NAMS of Ukraine»
  • V. Savchuk SI «Institute of Nephrology NAMS of Ukraine»
  • Y. Gonchar SI «Institute of Nephrology NAMS of Ukraine»
  • V. Krot SI «Institute of Nephrology NAMS of Ukraine»
  • I. Shifris SI «Institute of Nephrology NAMS of Ukraine»
  • O. Loboda SI «Institute of Nephrology NAMS of Ukraine»
Keywords: chronic kidney disease, dialysis, menopause, chorionic

Abstract

The chorionic gonadotropin (CGT) test is used to diagnose and monitor the course ofpregnancy, including ectopic, to detect fetal abnormalities, trophoblastic diseases, preeclampsia, ovarian tumors, lungs, stomach, intestine, bladder, kidneys, prostate. The level of CGT is often elevated in postmenopausal women treated with hemodialysis (HD). Its significance is still not well understood, and therefore requires further study. The aim of our work was to investigate the level of CGT in postmenopausal women treated with HD.

Methods. The determination of the level of CGT in 23 postmenopausal women treated with HD. The main inclusion criteria were as follows: oral informed consent of the patient to participate in the study, the presence of CKD stage VD and treatment of HD for at least 6 months. Exclusion criteria: severe functional disorders (liver, heart, respiratory failure), cancer processes, smoking, taking substitution hormonal therapy, lack of consent of the patient. The results were compared with the CGT levels in 20 healthy menopausal women (group II).

Results. A statistically significant difference was found between the I group (postmenopausal women treated with HD) and II group (women without chronic kidney disease (CKD) (t = 3.62, p = 0.001). It was also found that CGT was increased in 9 (39%) of 23 women treated with HD. The norm of CGT in postmenopausal women is <14.0 IU/L, therefore the deviation of the index in the I group (13.63 ± 2.83 IU/L) is within the reference values. However, it does not explain the statistically significant difference between the CGT indices in the I group compared to the II group (p<0.01). Possibly, the presence of CKD contributes to the increase in HGT.

Conclusions. Authentically higher rates of CGT in postmenopausal women treated with HD compared with women without CKD were detected. Thus, CKD can affect the serum level of CGT, probably due to disruption, but this issue has not been studied, and requires further investigation.

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Abstract views: 266
PDF Downloads: 118
Published
2018-06-11
How to Cite
Abrahamovych, K., Dudar, I., Savchuk, V., Gonchar, Y., Krot, V., Shifris, I., & Loboda, O. (2018). The level of chorionic gonadotropin in postmenopausal women with CKD V stage treated with hemodialysis. Ukrainian Journal of Nephrology and Dialysis, (2(58), 9-12. https://doi.org/10.31450/ukrjnd.2(58).2018.02

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