ASSOCIATION OF ADSORPTION-RHEOLOGICAL PROPERTIES OF URINE IN GLOMERULONEPHRITIS WITH MORPHOLOGICAL CHANGES OF RENAL STRUCTURES IN PATIENTS WITH HEMORRHAGIC VASCULITIS

O. Syniachenko; T. Bevzenko; P. Syniachenko; O. Diadyk

doi:10.31450/ukrjnd.2(42).2014.05

O. Syniachenko M. Gorky Donetsk National Medical University
T. Bevzenko M. Gorky Donetsk National Medical University
P. Syniachenko M. Gorky Donetsk National Medical University
O. Diadyk M. Gorky Donetsk National Medical University

DOI: https://doi.org/10.31450/ukrjnd.2(42).2014.05

Keywords: hemorrhagic vasculitis, glomerulonephritis, urine, adsorption, rheology.

Abstract

The aim of the work: to assess adsorption-rheological state of urine in patients with hemorrhagic vasculitis (HV) with glomerulonephritis (GN), comparing the indicators with the nature of the morphological changes of the glomeruli, tubules, interstitium and vessels of the kidneys.

Materials and methods. Microscopy of nephrobiopsy specimens was performed in 21 patients with HVwith GN, urinary syndrome and preserved renal function. Using computer tensiometers “MPT2-Lauda”, “ADSA-Toronto” and “PAT2-Sinterface” indicators of surface viscosity, surface elasticity, module of viscoelasticity, relaxation time (RT), dynamic surface tension (ST) of urine, inclination angle and phasic angle (FA) of tensiongrams were studied.

Results and discussion. GN in HV is accompanied by a significant increase in (11%) the equilibrium ST of urine in 57% of patients on the background of decrease (21%) of FA. Adsorption-rheological condition of urine depends on the sex ofpatients and blood pressure level, the relative density of this biological fluid (RT, FA), its content ofprotein and non-protein nitrogen products, glomerular filtration rate and morphological class of GN (ST). The severity of the some renal structures lesion, the level of immune deposits in the mesangium, endothelium of glomerular capillary and podocytes, the degree of plasmatic impregnation arterioles and vascular endothelial proliferation significantly affect the integrated physical and chemical properties of urine. Prognostic significance in relation to the severity of morphological changes in the kidneys has an indicator of ST.

Conclusions. Assessment of adsorption- rheological properties of urine is a diagnostic method of GN in HV, and variations of such physic-chemical parameters are determined by morphological class and the clinical course of renal pathology, correlated with the severity of glomerular, tubular, interstitium and vessels lesion

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