Chronic inflammation and progression of chronic kidney disease in patients with type 2 diabetes

T.  Mazur; N.  Demikhova; T.  Rudenko; A.  Yurchenko; O.  Yezhova; S.  Bokova; A.  Demikhov

doi:10.31450/ukrjnd.4(72).2021.05

T. Mazur Sumy State University https://orcid.org/0000-0003-3145-573X
N. Demikhova Sumy State University http://orcid.org/0000-0003-4139-1645
T. Rudenko Sumy State University http://orcid.org/0000-0002-5807-2053
A. Yurchenko Sumy State University https://orcid.org/0000-0002-9707-8829
O. Yezhova Sumy State University https://orcid.org/0000-0002-8916-4575
S. Bokova Sumy State University https://orcid.org/0000-0002-3426-9150
A. Demikhov Sumy State University

DOI: https://doi.org/10.31450/ukrjnd.4(72).2021.05

Keywords: chronic kidney disease, diabetes mellitus, proinflammatory markers, endothelial status, indicators of progression.

Abstract

Chronic inflammation, atherosclerosis, tubulointerstitial fibrosis, and vascular damage play a crucial role in the progression of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (DM). However, specific biomarkers that can determine the progression of diabetic kidney disease, including patients with minimal albuminuria, remain undefined.

The present study aimed to determine markers of chronic inflammation as indicators of CKD progression in patients with type 2 DM.

Methods. 45 patients with type 2 DM and stage 1-3 CKD were involved in this cross-sectional observational study. Analysis of cellular mechanisms of CKD progression was performed on the concentrations of endothelin-1 (ET-1), fibronectin (FN), tumor necrosis factor-alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), and monocyte chemoattractant protein (MCP) -1) in the serum.

Results. In patients with type 2 DM, an increasing trend in the majority of endothelial and proinflammatory mediators was found according to the CKD stages despite normal albuminuria.

Conclusions. Concentrations of TNF-α, ET, TGF-β1 and MCP-1 can be used to assess the progression of CKD in patients with type 2 DM with normal albuminuria. Further researches are needed to determine early indicators of diabetic kidney disease progression.

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References

Fomina, A. P. (2017). Diabetes mellitus, diabetic nephropathy, children: certain issues. Ukr J Nephrol Dial. 2017;1(53):58-69. doi: 10.31450/ukrjnd.1(53).2017.09.

Degen AS, Krynytska IY, Kamyshnyi AM. Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers. Endocr Regul. 2020;54(3):160-171. doi: 10.2478/enr-2020-0019.

Topchii I, Shcherban T, Galchinska V, Semenovykh P, Savicheva K. The level of vascular endothelial growth factor in peripheral blood of type 2 diabetic patients depending on kidney functional state. Ukr J Nephrol and Dial 2019;1(61):13-19. doi: 10.31450/ukrjnd.1(61).2019.02.

Kritsak M, Konovalenko S, Stechyshyn I, Pavliuk B. Biotechnological methods of local treatment of infected wounds in diabetes mellitus in an experiment. Pharmacologyonline. 2021;2:97-104.

Pavliuk B, Stechyshyn I, Kramar S, Chubka M, Hroshovyi T. Therapeutic efficacy of the developed gel "Xeliogel" on a burn wound model in rats. Pol Merkur Lekarski. 2020;48(287):331-334.

De Leeuw TG, Mangiarini L, Lundin R et al. Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - Evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: Study protocol for a randomized controlled trial. Trials. 2019:20(1):49. doi: 10.1186/s13063-018-3169-3.

Demikhova N, Cherkashyna L, Chernatska O et al. The relationship between lipid metabolism and albuminuria level with single nucleotide polymorphism -204a>c [rs 3808607] CYP7A1 gene in patients with 2 type diabetes mellitus and diabetic nephropathy. Romanian Journal of Diabetes, Nutrition and Metabolic Diseases. 2019; 26(3):253-261. doi: 10.2478/rjdnmd-2019-0026.

Chernatska O, Demikhova N, Rudenko T et al. Assesment of the lipid profile correction in patients with arterial hypertension and type 2 diabetes mellitus. Azerbaijan Medical Journal. 2019;1:95-99.

Chernatska O, Demikhova N. Improvement of treatment in persons with arterial hypertension and type 2 diabetes mellitus. Georgian Medical News. 2018;11(284):47-51.

Barchan GS, Cherkashyna LV, Shklyar AS, et al. Immune disorders in recurrent respiratory infections on the background of undifferentiated connective tissue dysplasia. Azerbaijan Med J. 2020;1:10-16. doi: 10.34921/amj.2020.27.15.002.

Kamyshnyi A, Krynytska I, Matskevych V, Marushchak M, Lushchak O. Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology. International Journal of Hypertension. 2020; Article ID 8019360. doi:10.1155/2020/8019360.

International Diabetes Federation. IDF Diabetes Atlas 9th edition 2019. International Diabetes Federation [Internet]. [cited 2020 Aug 21]. Available from : https://www.idf.org/aboutdiabetes/what-is-diabetes/facts-figures.html.

Marushchak M, Krynytska I. Insulin Receptor Substrate 1 Gene And glucose Metabolism Characteristics in Type 2 Diabetes Mellitus with Comorbidities. Ethiop J Health Sci. 2021;31 (5):1001-1010. doi: 10.4314/ejhs.v31i5.

Posokhova K, Stechyshyn I, Krynytska I, Marushchak M, Birchenko I, Klishch I. Comparative study of the effect of various forms of quercetin on experimental diabetes. Romanian Journal of Diabetes Nutrition and Metabolic Diseases. 2018;25(4):383-388. doi: 10.2478/rjdnmd-2018-0046.

Teslyk T, Yarmolenko O, Bumeister V et al. The remodeling of lungs under the influence of alloxan-induced hyperglycemia. Romanian Journal of Diabetes, Nutrition and Metabolic Diseases 27(1): 45-49, 2020. doi: 10.46389/rjd-2020-1008.

Savka II, Savka TB. Mechanisms of Macro-, Micro- and Ultramicroscopic Transformation of Bodies in Type 2 Diabetes. Ukr. ž. med. bìol. sportu. 2020; 5(2):36-42. doi: 10.26693/jmbs05.02.036.

Vons LZ, Martynyuk LP, Vodvud VK. Dynamics of indicators apoptosis white blood cells of patients having diabetes type 2 and chronic kidney disease. Achievements of Clinical and Experimental Medicine. 2016;4:32-35. doi: 10.11603/1811-2471.2016.v0.i4.7072.

Zelinska NB, Grishchenko KV, Globa EV. Type 2 diabetes mellitus in children and adolescents in the world and in Ukraine. Ukr J Pediatric Endocrin. 2021;1:416. doi: 10.30978/UJPE2021-1-4.

Loboda A, Smiyan O, Popov S, Petrashenko V, Zaitsev I, Redko O, et al. Child health care system in Ukraine. Turk Pediatri Ars. 2020;55(Suppl 1):98-104. doi: 10.14744/TurkPediatriArs.2020.82997.

Shkatula Y.V., Badion Y.O., Tkachenko Y.A. et al. Epidemiology of injuries in children resulting from a fall from a height. Azerbaijan Medical Journal. 2021; 2:113-119. doi: 10.34921/amj.2021.2.017.

Marushchak M, Lisnianska N, Krynytska І, Chornomydz I. The mechanisms of apoptosis initiation in rats with chronic enterocolitis combined with streptozotocin-induced diabetes. Georgian Med News. 2017;(270):125-130.

Krynytska I, Marushchak M, Zaets T, Savchenko I, Habor H. Investigation of bone mineralization in patients with coronary heart disease complicated by chronic heart failure, stage II-A. Georgian Med News. 2017;(267):43-48.

Stepanova N, Snisar L, Lebid L, Driianska V. Crosstalk between proteinuria, plasma oxalic acid and inflammation in glomerulonephritis patients: an exploratory study. Ukrainian Journal of Nephrology and Dialysis. 2021;3(71):19-27. doi:10.31450/ukrjnd.3(71).2021.03.

Yarmolenko O., Bumeister V., Demikhova N. et al. The effect of alloxan-induced hyperglycemia on the myocardium of experimental animals. Romanian Journal of Diabetes, Nutrition and Metabolic Diseases. 2020; 27(2):80–84. doi: 10.46389/rjd-2020-1014.

Shuliarenko LV. Khronichna diabetychna khvoroba nyrok: suchasnyi pohliad na problemu. Endokrynolohiia. 2013;18 (1):73-82. [In Ukrainian].

Demikhov O, Dehtyarova I, Rud O, et al. Arterial hypertension prevention as an actual medical and social problem. Bangladesh J Med Sci. 2020;19(4): 722-729. doi: 10.3329/bjms.v19i4.46632.

Demikhova N, Sukhonos V, Vynnychenko L, et al. Activation of lipid peroxidation in patients with renal hypertension. Georgian Med News. 2013; 215: 51-55. [In Russian].

Popov S, Demikhova N, Melekhovets O et al. Application of "reytoil" in prevention of atherosclerosis in diabetes patients. Lіkars`ka sprava. 2012;8:119-126. [In Ukrainian].

Marushchak M, Krynytska I, Milevska L, Miz A, Mialiuk O. The changes of activity of effector caspase cascade components in case of alimentary obesity in rats. Bangladesh Journal of Medical Science. 2017;16(2): 252-258. doi: 10.3329/bjms.v16i2.31280.

Marushchak M, Krynytska І, Mazur L, Klishch I, Gabor G, Antonyshyn. The Relationship between Experimental Alimentary Obesity and Hard Tooth Tissues Mineralization. Jordan Medical Journal. 2017;51(1): 25-33. doi: 10.12816/0039753.

Didushko OM. Type 2 diabetes mellitus and chronic kidney disease: modern opportunities for antihyperglycemic therapy. The Practitioner. 2020;3-4:21-25.

Zhang XX, Kong J, Yun K. Prevalence of Diabetic Nephropathy among Patients with Type 2 Diabetes Mellitus in China: A Meta-Analysis of Observational Studies. Journal of Diabetes Research. 2020. Article ID: 2315607. doi: 10.1155/2020/2315607.

Gaĭseniuk FZ, Driianskaia VE, Drannik GN, Rudenko MIu, Lavrenchuk OV, Stepanova NM, et al. Proinflammatory cytokines in patients with pyelonephritis. Lik Sprava. 2013 Sep;(6):32-7. [In Russian].

Korol L, Mygal Y, Stepanova N. Intensity of oxidative stress and activity of angiotensin converting enzyme in blood of patients with uncomplicated pyelonephritis. Ukrainian Biochem J. 2017; 89(2): 99-105. doi: 10.15407/ubj89.02.099.

Lundin U, Weinberger KM. Towards Metabolic Biomarkers for the Diagnosis and Prognosis of CKD. Advances in Nephropathy. In: Advances in Nephropathy (Eds Thomas Rath) 2018; 19-61. doi: 10.5772/intechopen.80335.

Korol L, Stepanova N, Vasylchenko V, Snisar L, Lebid L, Kolesnyk M. Plasma oxalic acid as a trigger for oxidative processes in end-stage renal disease patients. Ukr J Nephr Dial. 2021;1(69):46-53. doi: 10.31450/ukrjnd.1(69).2021.07.

Хиць А.Р. Хронічна хвороба нирок та цукровий діабет: менеджмент пацієнтів у світлі останнього гайдлайну KDIGO 2020 р. УКР. МЕД. ЧАСОПИС, 2021. Available from : https://www.umj.com.ua/wp/wp-content/uploads/2021/06/Strygak.pdf?upload=

Szczech L.A., Stewart R.C., Su H.L., DeLoskey RJ, Astor BC, Fox CH, et al. Primary care detection of chronic kidney disease in adults with type-2 diabetes: the ADD-CKD Study (awareness, detection and drug therapy in type 2 diabetes and chronic kidney disease). PLoS One. 2014; 9(11): e110535. doi: 10.1371/journal.pone.0110535.

Yarmolenko O, Bumeister V, Polak S, Gordienko O, Prykhodko O, Demikhova N, et al. The effect of the experimental chronic hyperglycemia on the kidney and myocardium. Ukr J Nephrol Dial. 2021;3(71):3-10. doi: 10.31450/ukrjnd.3(71).2021.01.

Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis GA, Vogiatzi G, Papaioannou S, et al. The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives. Eur Cardiol. 2019 Apr;14(1):50-59. doi: 10.15420/ecr.2018.33.1.

Shifris IM. Diabetic status, comorbidity and survival in patients with chronic kidney dise ase stage vd st.: a cohort study. Problems of Endocrine Pathology. 2021;72(2):95-103. doi:10.21856/j-PEP.2020.2.12.

Cherkashyna L, Konoval N, Shklyar A et al. Study of structural and biochemical changes in the muscular tissue of the oesophagus for solving the problem of diagnosing the prescription of death coming. Pol Merkur Lekarski. 2020;48(283):42-44.

Demikhova NV, Smiianov VA, Prikhodko OA, et al. Information and telecommunication technologies and problem-based learning (PBL) in the formation of competitive competence in medical masters of Sumy state university. Azerbaijan Med J. 2016;2: 95-101.

Sysoyeva L, Bielova I, Ryabushka L, et al. Determinants of management of central bank to provide the economic growth: An application of structural equation modeling. Estudios de Economia Aplicadathis. 2021;39(5). doi: 10.25115/eea.v39i5.4803.

Voloshchuk N, Konjuch S, Melnyk A, Denysiuk O. The influence of genistein, resveratrol and quercetin on functional state of kidney in rats with experimental chronic kidney disease. Connection with hydrogen sulfide system. Modern Science – Moderní věda. 2020;2: 82-93.

Sharif S, Van der Graaf Y, Cramer MJ, Kapelle LJ, de Borst GJ, Visseren FLJ, Westerink J; SMART study group. Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes. Cardiovasc Diabetol. 2021;20:220. doi: 10.1186/s12933-021-01409-0.

Ostrovskyy M, Korzh N Systemic inflammatory markers and overweight in patients suffering from chronic obstructive pulmonary disease with ііі degree of bronchial obstruction. Аsthma and Allergy, 2019;2: 10-16. [In Ukrainian].

Piliponova VV, Slobodianyk VA The role of kidneys endothelial dysfunction in the pathogenesis of diseases and their complications (Review of literature). Achievements of Clinical and Experimental Medicine. 2019;3:32–39. [In Ukrainian]. doi: 10.11603/1811-2471.2019.v.i3.10503.

Krynytska I, Marushchak M. The indices of nitrogen (II) oxide system in experimental hepatopulmonary syndrome. Ukrainian Biochemical Journal. 2018;90(5):91-97. doi: 10.15407/ubj90.05.091.

Kuzmenko EV, Kulinich GV, Sorochan PP, Savchenko AS. Role of transforming growth factor TGF-β1 in pathogenesis of malignant neoplasms. Ukrainian Journal of Radiology. 2015;XXIII (PUB. 1): 30-34. [In Russian].

Tsymbal TS. Features of the pathogenesis and treatment of diabetic nephropathy (literature review and own data). Endocrinology. 2013; 18(4): 63-70. [In Ukrainian].

Petreski T, Piko N, Ekart R, Hojs R, Bevc S. Review on Inflammation Markers in Chronic Kidney Disease. Biomedicines. 2021;9(2):182. doi: 10.3390/biomedicines9020182.

Furuya F, Ishii T, Kitamura K. Chronic Inflammation and Progression of Diabetic Kidney Disease. Contrib Nephrol. 2019;198:33-39. doi: 10.1159/000496526.