The role of vitamins K and D in the processes of ectopic calcification in patients with chronic kidney disease: The current state of the problem

  • O. Susla I. Horbachevsky Ternopil National Medical University https://orcid.org/0000-0002-1078-5898
  • O. Bushtynska I. Horbachevsky Ternopil National Medical University
  • S. Danyliv I. Horbachevsky Ternopil National Medical University
  • L. Logoyda I. Horbachevsky Ternopil National Medical University
  • A. Gozhenko SE «Ukrainian Scientific-Research Institute of Transport Medicine of Ministry of Health of Ukraine»
DOI: https://doi.org/10.31450/ukrjnd.3(75).2022.09
Keywords: chronic kidney disease, cardiovascular system, ectopic calcification, atherosclerosis, vitamin K, vitamin D, matrix Gla protein, osteocalcin, pathogenesis, treatment.

Abstract

Abstract. The generalization of experimental and clinical data currently allows us to confirm the important pathogenetic role of vitamin K deficiency in cardiovascular calcification and atherosclerotic damage in chronic kidney disease (CKD). It was highlighted that, apart from vitamin K, the activity and expression of matrix Gla protein, which strongly inhibits vascular calcification, depended to a considerable extent on vitamin D. The efficacy and safety of the combined intake of vitamin K and D in slowing the progression of ectopic calcification, reducing cardiovascular risk, and improving prognosis in CKD patients need to be confirmed in multicenter randomized controlled trials.

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Published
2022-08-02
How to Cite
Susla, O., Bushtynska, O., Danyliv, S., Logoyda, L., & Gozhenko, A. (2022). The role of vitamins K and D in the processes of ectopic calcification in patients with chronic kidney disease: The current state of the problem. Ukrainian Journal of Nephrology and Dialysis, (3(75), 73-82. https://doi.org/10.31450/ukrjnd.3(75).2022.09
Issue
No 3(75) (2022): Ukrainian Journal of Nephrology and Dialysis
Section
Nephrology School
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