THE PROGRESSION OF СHRONIC KIDNEY DISEASE: STATE OF OXIDATIVE STRESS AT DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE
Abstract
The aim of study was to evaluate the activity of lipid peroxidation and antioxidant status in patients with chronic kidney disease (CKD) I-V st. It was shown that the development of CKD is accompanied by increased lipid peroxidation in the background of decreased activity of the antioxidant status. With the progression of CKD observed a significant elevation in lipid peroxidation activity - raising the levels of serum MDA and MDA erythrocytes. The activity was significantly decreased antioxidant status with the progression of the disease - reducing levels of SH-groups and on the total peroxidase activity of erythrocytes.
Downloads
References
Oxidative stress and inflammation in renal patients and healthy subjects [Електронний ресурс] / D. M. Lee, K. W. Jackson, N. Knowlton [et al.] // PLoS ONE. – 2011. – Vol. 6(7) : e22360. Режим доступу до статті : http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022 360
Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options [Текст] / M. P. Kao, D. S. Ang, A. Pall, A. D. Struthers // J. Hum. Hypertens. – 2010. – Vol. 24(1). – P. 1–8.
Descamps-Latscha B. Dialysis-induced oxidative stress: biological aspects, clinical consequences, and therapy [Текст] / B. Descamps-Latscha, T. Drueke, V. Witko-Sarsat // Semin. Dial. – 2001. – Vol. 14(3). – P. 193–199.
Del Vecchio L. What we know about oxidative stress in patients with chronic kidney disease on dialysis—clinical effects, potential treatment, and prevention [Текст] / L. Del Vecchio, F. Locatelli, M. Carini // Semin. Dial. – 2011. – Vol 24 (1) – P. 56–64.
Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane [Текст] / H. Noh, J. S. Kim, K. H. Han[et al.] // Kidney Int. – 2006. – Vol. 69(11). – P. 2022-2028.
Markers of inflammation and oxidative stress in peritoneal dialysis: a comparison between high and low peritoneal transporters [Текст] / D. N. Cruz, S. S. Soni, N. Polanco [et al.] // J. Nephrol. – 2010. – Vol. 23(4). – P. 453-458.
Study of oxidative stress in advanced kidney disease [Текст] / M. J. Puchades Montesa, M. A. González Rico, M. A. Solís Salguero [et al.] // Nefrología. – 2009. – Vol. 29 (5). – P. 464-473.
Finkel T. Oxidant signals and oxidative stress [Текст] / T. Finkel // Current Opinion in Cell Biology. – 2003. – Vol. 15 (2) – P. 247–254.
Nathan C. Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling [Текст] / C. Nathan // Journal of Clinical Investigation. – 2003. – Vol. 111 (6). – P. 769–778.
.Стальная И. Д. Метод определения малонового диальдегида с помощью тиобарбитуровой кислоты [Текст] / И. Д. Стальная, Т. Г. Гаришвили // Сборник "Современные методы в биохимии". – М.: Медицина, 1977. – С. 66-67.
.Камышников В. С. Справочник по клинико-биохимической лабораторной диагностике [Текст] / В. С. Камышников. – Минск : “Беларусь”. – 2002, Т.1. – 495 с.
.Попов Т. Метод определения пероксидазной активности крови [Текст] / Т. Попов, Л. Нейковска // Гигиена и санитария. – 1971. – №1. – С. 89-91.
Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle? [Текст] / P. Stenvinkel, J. Je. Carrero, J. Axelsson [et al.] // CJASN. – 2008. – Vol. 3. – P. 505-521.
