Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospital

DOI: https://doi.org/10.31450/ukrjnd.4(84).2024.02
Keywords: end-stage kidney disease, renal cell carcinoma, acquired cystic kidney disease, hemodialysis, pathology.

Abstract

End-stage kidney disease (ESKD) is associated with a higher incidence of renal cell carcinoma (RCC). Here we report a case series of 56 patients with ESKD who underwent radical nephrectomy for suspected renal masses at a tertiary hospital in Portugal from January 2017 to January 2024. Patient records were reviewed retrospectively to collect clinical, surgical, and pathological data. Among these patients, 12 had benign tumors, while 44 were diagnosed with malignant tumors, accounting for approximately 78.5% of the cohort. The histological analysis revealed the following distribution: clear cell RCC (20 cases, 45%), papillary RCC (11 cases, 25%), ACKD-associated RCC (6 cases, 14%), clear cell papillary RCC (4 cases, 9%), and chromophobe RCC (3 cases, 7%). Notably, the majority of patients (95.5%) had stage I malignant tumors, yet the prognosis for patients with ESKD was poorer compared to non-ESKD patients, with 7 patients succumbing during the follow-up period.

This study underscores the complex relationship between ESKD and RCC, highlighting the challenges in diagnosis and management. Despite regular monitoring leading to early detection of tumors, the overall prognosis remains adversely affected by the compromised immune status and comorbid conditions prevalent in this population. The findings call for enhanced surveillance and personalized management strategies for RCC in patients with ESKD.

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References

Elendu C, Elendu RC, Enyong JM, Ibhiedu JO, Ishola IV, Egbunu EO, et al. Comprehensive review of current management guidelines of chronic kidney disease. Medicine (Baltimore). 2023;102(23):e33984. doi: 10.1097/MD.0000000000033984.

Mallamaci F, Tripepi G. Risk Factors of Chronic Kidney Disease Progression: Between Old and New Concepts. J Clin Med. 2024;13(3):678. doi: 10.3390/jcm13030678.

Kompotiatis P, Thongprayoon C, Manohar S, Cheungpasitporn W, Gonzalez Suarez ML, Craici IM, et al. Association between urologic malignancies and end-stage renal disease: A meta-analysis. Nephrology (Carlton). 2019 ;24(1):65-73. doi: 10.1111/nep.13209.

Hora M, Hes O, Reischig T, Urge T, Klecka J, Ferda J, et al. Tumours in end-stage kidney. Transplant Proc. 2008;40(10):3354-8. doi: 10.1016/j.transproceed.2008.08.135.

Song C, Hong SH, Chung JS, Byun SS, Kwak C, Jeong CW, et al. Renal cell carcinoma in end-stage renal disease: Multi-institutional comparative analysis of survival. Int J Urol. 2016;23(6):465-71. doi: 10.1111/iju.13084.

Tsuzuki T, Iwata H, Murase Y, Takahara T, Ohashi A. Renal tumors in end-stage renal disease: A comprehensive review. Int J Urol. 2018;25(9):780-786. doi: 10.1111/iju.13759.

Yoshida M, Yao M, Ishikawa I, Kishida T, Nagashima Y, Kondo K,et al. Somatic von Hippel–Lindau disease gene mutation in clear-cell renal carcinomas associated with end-stage renal disease/acquired cystic disease of the kidney. Genes Chromosom. Cancer 2002; 35: 359–64. doi: 10.1002/gcc.10123.

Kuntz E, Yusenko MV, Nagy A, Kovacs G. Oligoarray comparative genomic hybridization of renal cell tumors that developed in patients with acquired cystic renal disease. Hum. Pathol. 2010; 41 (9): 1345–9. doi: 10.1016/j.humpath.2009.09.022.

Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur Urol. 2016;70(1):93-105. doi: 10.1016/j.eururo.2016.02.029.

Kondo T, Sassa N, Yamada H, Takagi T, Iizuka J, Kobayashi H, et al. Comparable survival outcome between acquired cystic disease associated renal cell carcinoma and clear cell carcinoma in patients with end-stage renal disease: a multi-institutional central pathology study. Pathology. 2021;53(6):720-727. doi: 10.1016/j.pathol.2021.01.014.

Toyokuni S. The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy. Pathol Int. 2016;66(5):245-59. doi: 10.1111/pin.12396.

Tickoo SK, dePeralta-Venturina MN, Harik LR, Worcester HD, Salama ME, Young AN, et al. Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. Am J Surg Pathol. 2006;30(2):141-53. doi: 10.1097/01.pas.0000185382.80844.b1.

Nouh MA, Kuroda N, Yamashita M, Hayashida Y, Yano T, Minakuchi J, et al. Renal cell carcinoma in patients with end-stage renal disease: relationship between histological type and duration of dialysis. BJU Int. 2010;105(5):620-7. doi: 10.1111/j.1464-410X.2009.08817.x.

Sassa N, Hattori R, Tsuzuki T, Watarai Y, Fukatsu A, Katsuno S, et al. Renal cell carcinomas in haemodialysis patients: does haemodialysis duration influence pathological cell types and prognosis? Nephrol Dial Transplant. 2011;26(5):1677-82. doi: 10.1093/ndt/gfq529.

Klatte T, Seitz C, Waldert M, de Martino M, Kikic Z, Böhmig GA, et al. Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients. BJU Int. 2010;105(9):1260-5. doi: 10.1111/j.1464-410X.2009.08941.x.

Neuzillet Y, Tillou X, Mathieu R, Long JA, Gigante M, Paparel P, et al. Renal cell carcinoma (RCC) in patients with end-stage renal disease exhibits many favourable clinical, pathologic, and outcome features compared with RCC in the general population. Eur Urol. 2011 ;60(2):366-73. doi: 10.1016/j.eururo.2011.02.035.


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Published
2024-10-05
How to Cite
Guerra, J. F., Pina, J. M., Andrade, V., Brito Lança, M., & Campos Pinheiro, L. (2024). Renal carcinoma associated with end-stage kidney disease: A case series from a tertiary Portuguese hospital. Ukrainian Journal of Nephrology and Dialysis, (4(84), 17-22. https://doi.org/10.31450/ukrjnd.4(84).2024.02
Issue
No 4(84) (2024): Ukrainian Journal of Nephrology and Dialysis
Section
Сlinical Сase Reports

Copyright (c) 2024 Ukrainian Journal of Nephrology and Dialysis

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