OXIDATIVE PROCESS IN PATIENTS WITH RECURRENT PYELONEPHRITIS AND RELATIONSHIP WITH RENAL SCARRING
Abstract
The purpose of our study was to analyze the intensity of oxidative process in patients with recurrent pyelonephritis and to determine the relationship between indicators of lipid peroxidation / antioxidant and the number of renal scars.
Methods. The study involved 117 women with chronic pyelonephritis and 30 conditionally healthy persons. We studied the parameters of oxidant / antioxidant balance of blood. In addition, we used DMSA renal scintigraphy. After the examination patients were divided into II groups: I (n=65) – women with recurrent pyelonephritis and II (n=52) – patients without frequent recuring of the disease (up to 2 times per year).
Results. For all patients with pyelonephritis, is higher than conventionally healthy donors were characterized by growth in production of malondialdehyde (MDA) in serum and in red blood cells, against a background of reducing the total peroxidase activity (SPA) and transferrin (TR) (3,4±0,9 and 5,2±1,0 respectively, p<0.001). In patients with recurrent pyelonephritis was defined the highest level of MDAs (p=0,01) and decrease of antioxidant proteins: TR (p=0.02) and ceruloplasmin (CP) (p=0.03). We found inverse correlation between the number of recurrences of pyelonephritis per year and the activity of CP and TP (r=-0,36; p=0,008 and r=-0,38; p=0,004 respectively).
Conclusions. In all examined patients identified an imbalance of lipid peroxidation and antioxidant systems, which was accompanied by activation of lipid peroxidation against deficiency of antioxidant. In patients with recurrent pyelonephritis determined significantly higher intensity of oxidative process and the lowest of antioxidant protection, which can be one of the risk factors for the formation of renal "scars". Further studies are needed to finally resolve this issue.
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References
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