MYCOPHENOLATE MOFETYL IN CHILDREN WITH GLOMERULONEPHRITIS: STEROID SENSITIVE NEPHROTIC SYNDROME EXPERIENCE
Abstract
The aim of the study was to investigate the efficiency of mycophenolate mofetil (MMF) in the treatment Protocol in children with steroid sensitive nephrotic syndrome (SS NS).
Patients and methods. Disease outcome was studied in 20 patients treated by MMF after relapse in years 2004-2007 (selected occasionally), and in 30 children with early relapse after alkylating agent treatment (years 2008-2012). MMF was administered in dose 500-600 mg/m2/day for 12 months after induction remission by steroids (Protocol MMF).
Results. In first group (years 2004-2007) after Protocol MMF withdrawal remission persisted in 50.0% at 24 months, and in 35.0% at last follow up (60 months). Patients from the second group (years 2008-2012) maintained remission at 24 months in 60.0% Furthermore, the early relapses level in the second group decreased threefold (6.7% vs. 20.0% in years 2004-2007).
Conclusion. The proposed Protocol MMF had a reason and a good safety profile in children with SS NS. Reduction of relapse risk and prolongation of remission were observed in patients with second relapse of NS. Protocol MMF in patients with early relapse after treatment by prednisone and alkylating agent has contributed to avoid steroid dependence and frequent relapsing NS course.
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References
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