Onconephrological care: Why it is necessary and how to organize it in Ukraine

  • M. Kolesnyk State Institution “O.O. Shalimov National Scientific Center of Surgery and Transplantology of the National Academy of Medical Science of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0001-6658-3729
Keywords: onconephrology, chronic kidney disease, acute kidney injury, glomerular filtration rate.

Abstract

In recent years, there has been a significant increase in the need for nephrologists to participate in the treatment of cancer patients. The reasons for this are the high incidence of kidney involvement in cancer patients and the increase in the prevalence of malignant processes in nephrological patients.

There are many reasons for kidney damage in patients with oncopathology (drug-induced, paraneoplastic lesions, etc.), and in patients with chronic kidney disease (CKD) I-V, VD, and VT the risk of malignant diseases is significantly higher than in the general population.  In both groups of patients, kidney function is a qualificatory determinant of the volume and effectiveness of treatment, duration, and quality of life.The complexity of the relationship between oncopathology and the kidneys, acute kidney injury (AKI), CKD, and oncopathology dictates the urgent need for both training of specialists in onconephrology and determining the organizational principles of the functioning of this type of specialized medical care.

Thus, interdisciplinary knowledge and experience which will be implemented through the subspecialty "onconephrology", training of nephrologists in this important component of modern nephrology and the creation of outpatient or hospital units is a crucial stage in the organization of specialized medical care for nephrological patients in general and onconephrology profile in particular.

Conclusions. Onconephrology is an important component of specialized medical care for cancer patients; Its implementation will improve the prevention, diagnosis of kidney damage, treatment outcomes, and the quality and duration of life of such patients.

The National Expert Group "Onconephrology" of the Ukrainian Association of Nephrologists and Kidney Transplantation Specialists (UAN and KTS) through the creation of an appropriate specialization program in nephrology, training of nephrologists, oncologists, the use of all available forms of raising awareness can contribute to the development of onconephrological care in Ukraine.

Supercluster health care facilities of hospital counties will be the basic institutions for providing onconephrological care to patients.

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References

Alonso F, Auñón P, Cavero T, Salgueira M, Praga M, Quiroga B, et al. Monographic consultation of onconephrology. Rationale and implementation. Nefrologia. 2021;41(2):154-164. doi: 10.1016/j.nefroe.2021.04.006. 

Li Y, Chen X, Wang Y, Hu J, Hu J, Jiang W, et al. Epidemiology of acute kidney injury and associated factors among patients with malignancy: Analysis of hospital inpatient database in Shanghai, China. J Onco-Nephr. 2019; 3: 39-48. doi: 10.1177/2399369319830096. 

Christiansen CF, Johansen MB, Langeberg WJ, Fryzek JP, Sørensen HT. Incidence of acute kidney injury in cancer patients: a Danish population-based cohort study. Eur J Intern Med. 2011;22(4):399-406. doi: 10.1016/j.ejim.2011.05.005. 

Launay-Vacher V, Oudard S, Janus N, Gligorov J, Pourrat X, Rixe O, et al. Prevalence of Renal Insuffiency in cancer patients and implications for anticancer drug management: the renal insufficiency and anticancer medications (IRMA) study. Cancer. 2007;110(6):1376-84. doi: 10.1002/cncr.22904. 

Janus N, Launay-Vacher V, Byloos E, Machiels JP, Duck L, Kerger J, et al. Cancer and renal insufficiency results of the BIRMA study. Br J Cancer. 2010;103(12):1815-21. doi: 10.1038/sj.bjc.6605979. 

Wong G, Staplin N, Emberson J, Baigent C, Turner R, Chalmers J, et al. Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies. BMC Cancer. 2016;16:488. doi: 10.1186/s12885-016-2532-6. 

Jhaveri KD, Shah HH, Calderon K, Campenot ES, Radhakrishnan J. Glomerular diseases seen with cancer and chemotherapy: a narrative review. Kidney Int. 2013;84(1):34-44. doi: 10.1038/ki.2012.484. 

de Francisco ALM, Macía M, Alonso F, García P, Gutierrez E, Quintana LF, et al. Onco-Nefrología: cáncer, quimioterapia y riñón. Nefrologia. 2019;39(5):473-481. doi: 10.1016/j.nefro.2018.10.016. 

Cosmai L, Porta C, Gallieni M, Perazella MA. Onco-nephrology: a decalogue. Nephrol Dial Transplant. 2016;31(4):515-9. doi: 10.1093/ndt/gfv320. 

Salahudeen AK, Bonventre JV. Onconephrology: the latest frontier in the war against kidney disease. J Am Soc Nephrol. 2013;24(1):26-30. doi: 10.1681/ASN.2012070690. 

Abudayyeh AA, Lahoti A, Salahudeen AK. Onconephrology: the need and the emergence of a subspecialty in nephrology. Kidney Int. 2014;85(5):1002-4. doi: 10.1038/ki.2014.29. 

Finkel KW, Howard SC. Onco-nephrology: an invitation to new field. J Clin Oncol. 2014;32(22):2389-90. doi: 10.1200/JCO.2014.56.5622. 

Capasso A, Benigni A, Capitanio U, Danesh FR, Di Marzo V, Gesualdo L, et al. Summary of the International Conference on Onco-Nephrology: an emerging field in medicine. Kidney Int. 2019;96(3):555-567. doi: 10.1016/j.kint.2019.04.043. 

Iff S, Craig JC, Turner R, Chapman JR, Wang JJ, Mitchell P, Wong G. Reduced Estimated GFR and Cancer Mortality. Am J Kidney Dis. 2014;63(1):23-30. doi: 10.1053/j.ajkd.2013.07.008. 

Wong G, Hayen A, Chapman JR, Webster AC, Wang JJ, Mitchell P, Craig JC. Association of ХХН and Cancer Risk in Older People. J Am Soc Nephrol. 2009;20(6):1341-50. doi: 10.1681/ASN.2008090998. 

Butler AM, Olshan AF, Kshirsagar AV, Edwards JK, Nielsen ME, Wheeler SB, Brookhart MA. Cancer incidence among US Medicare ESRD patients receiving hemodialysis, 1996-2009. Am J Kidney Dis. 2015;65(5):763-72. doi: 10.1053/j.ajkd.2014.12.013. 

Au E, Wong G, Chapman JR. Cancer in kidney transplant recipients. Nat Rev Nephrol. 2018;14(8):508-520. doi: 10.1038/s41581-018-0022-6. 

Salahudeen AK, Doshi SM, Pawar T, Nowshad G, Lahoti A, Shah P. Incidence rate, clinical correlates, and outcomes of ГПН in patients admitted to a comprehensive cancer center. Clin J Am Soc Nephrol. 2013;8(3):347-54. doi: 10.2215/CJN.03530412. 

Cerqueiro Gonzalez JM, Terrón Pérez F, Abeledo Vázquez C, López Díaz MJ, Matesanz Fernández M, Casariego Vales E. Resultados asistenciales de una consulta monográfica para pacientes con insuficiencia cardíaca. Estudio de cohortes. Galicia Clin. 2010; 71 (3): 103-110. 

Fuster A, Chacon L, Bauza J, S. Torres, Mir I. Efficacy of a special COPD consultation in reducing hospital admissions and emergency room visits. Eur Respir J. [Internet]. 2013; 42,Suppl. 57: 1869. Available from: https://www.ers-education.org/lr/show-details/?idP=127272. 

Cisneros C, Díaz-Campos RM, Marina N, Melero C, Padilla A, Pascual S, et al. Accreditation of specialized asthma units for adults in Spain: an applicable experience for the management of difficult-to-control asthma. J Asthma Allergy. 2017 May 9;10:163-169. doi: 10.2147/JAA.S131506. 

Bilbao Goyoaga T, Quilez N, Comeche L, Alvaro J, Diez M, Perez R, et al. More than two years of a monographic consultation on control of chronic home oxygen therapy. Eur Respir J. 2011;38:542.

Calvet Fontova J, Orellana C, Navarro N, Garcia-Manrique M,Galisteo C, Gratacos J, et al. Monographic Consultation of patients with knee osteoarthritis with joint effusion: specific care model. Experience after one year. Ann Rheum Dis. 2015;74:1183. doi: 10.1136/annrheumdis-2015-eular.3970. 

ACERCA (Acreditación de Calidad de las Unidades deEnfermedad Renal Crónica Avanzada). Available from: https://senefro.org/modules.php?name=grupos&dop=viewgroup&idgroup=14244&idgroupcontent=1704.

Arjona Barrionuevo Jde D, Gonzales Vargas-Machuca M, Guerrero Márquez FJ, Gil-Sacaluga L, Gentil-Govantes MA. Utility of a cardiorenal monographic consultation to reduce the cardiovascular mortality of the renal transplant patient. J Cardiol Cardiovasc Sci. 2019;3(3):1-8. doi: 10.29245/2578-3025/2019/3.1170.

Rosner MH, Perazella MA. Acute Kidney Injury in Patients with Cancer. N Engl J Med. 2017;376(18):1770-1781. doi: 10.1056/NEJMra1613984. 

Lam AQ, Humphreys BD. Onco-nephrology: AKI in the cancer patient. Clin J Am Soc Nephrol. 2012;7(10):1692-700. doi: 10.2215/CJN.03140312. 

Izzedine H, Perazella MA. Anticancer drug-induced acute kidney injury. Kidney Int Rep. 2017;2(4):504-514. doi: 10.1016/j.ekir.2017.02.008. 

Jhaveri KD, Wanchoo R, Sakhiya V, Ross DW, Fishbane S. Adverse Renal Effects of Novel Molecular Oncologic Targeted Therapies: A Narrative Review. Kidney Int Rep. 2016 Sep 21;2(1):108-123. doi: 10.1016/j.ekir.2016.09.055. 

de Francisco ALM, Arias Guillén M, Pérez-Valderrama B, Sebastia C. Post-contrast acute kidney injury in cancer patients. Nefrologia (Engl Ed). 2019;39(6):563-567. doi: 10.1016/j.nefro.2019.02.001. 

Torres da Costa E Silva V, Costalonga EC, Coelho FO, Caires RA, Burdmann EA. Assesment of Kidney Function in patients with cancer. Adv Chronic Kidney Dis. 2018;25(1):49-56. doi: 10.1053/j.ackd.2017.10.010.

Sprangers B, Abudayyeh A, Latcha S, Perazella MA, Jhaveri KD. How to determine kidney function in cancer patients? Eur J Cancer. 2020;132:141-149. doi: 10.1016/j.ejca.2020.03.026. 

Chancharoenthana W, Wattanatorn S, Vadcharavivad S. et al. Agreement and precision analyses of various estimated glomerular filtration rate formulae in cancer patients. Sci Rep. 2019; 9: 19356. doi: 10.1038/s41598-019-55833-0. 

He L, Li J, Zhan J, Yi F, Fan X, Wei Y, Zhang W. The value of serum cystatin C in early evaluation of renal insufficiency in patients undergoing chemotherapy: a systematic review and meta-analysis. Cancer Chemother Pharmacol. 2019;83(3):561-571. doi: 10.1007/s00280-018-3762-x. 

Soukup T, Lamb BW, Arora S, Darzi A, Sevdalis N, Green JS. Successful strategies in implementing a multidisciplinary team working in the care of patients with cáncer: an overview and synthesis of the available literature. J Multidiscip Healthc. 2018;11:49-61. doi: 10.2147/JMDH.S117945. 

Cosmai L, Porta C, Perazella MA, Launay-Vacher V, Rosner MH, Jhaveri KD, et al. Opening an onconephrology clinic: recommendations and basic requirements. Nephrol Dial Transplant. 2018;33(9):1503-1510. doi: 10.1093/ndt/gfy188. 

Deiaki pytannia orhanizatsii spromozhnoi merezhi zakladiv okhorony zdorovia: postanova KMU vid 28.02.2023 № 174. [Internet]. Available from: https://www.kmu.gov.ua/npas/deiaki-pytannia-orhanizatsii-spromozhnoi-merezhi-zak-a174. [In Ukrainian]. 


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Published
2024-03-01
How to Cite
Kolesnyk, M. (2024). Onconephrological care: Why it is necessary and how to organize it in Ukraine. Ukrainian Journal of Nephrology and Dialysis, (2(82), 7-13. https://doi.org/10.31450/ukrjnd.2(82).2024.02