INFLUENCE OF GLICEROL ON FUNCTIONAL-MORPHOLOGICAL INDICATORS OF KIDNEYS AT MODELLING RENAL INSUFFICIENCY IN RATS

  • I. I. Kondakov
  • I. I. Topchii
  • O. M. Kirienko
Keywords: model of acute kidney insufficiency, indexes of the functional state of kidneys, morphometric description, glycerol

Abstract

It is known, that after acute damage of kidney there is a risk of development of chronic kidney desease and death rate from its complications.

Material and methods. Research are spent on 40 not purebred rats at modelling of acute damage of the kidneys caused by toxic doses of glycerol. To evaluate histopathologal changes , we used cuts of fabrics painted gematoksilin- eozinom. Ultrathin preparations analyzed in electronic microscope PЕМ-125К.

Results. Administration of glycerol leads to uremia with dystrophic changes in tubular device and glomerular hypertrophy. At a stage of chronic renal insufficiency reduction of the glomerular sizes, tubulointerstitial fibrosis and glomerulosclerosis is observed.

Conclusion. At modelling of a nephritic pathology by introduction of 50 % glycerol infringement of function of kidneys has phasic character with probable development of chronic kidney desease in 8 weeks.

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References

Берхин Е.Б. Методы экспериментального исследования почек и водно- солевого обмена / Берхин Е.Б., Иванов Ю.И. – Барнаул: Алтайское книжн. изд-во, 1972. – 199 с.

Колесник М. Проект національних клінічних настанов з діагностики, профілактики і лікування гострого пошкодження нирок / Колесник М., Законь К., Дударенко В. //Український журнал нефрології та діалізу. – 2013. – N1. – С. 51-57

Казаченко А.В. Протекторная и регенерационная терапия при остром и хроническом повреждении почки. /Автореф. Докт. дисс.Москва, 2009. 41 с.

Кирпатовский В.И. Экспериментальная оценка новых технологий профилактики и лечения почечной недостаточности / Кирпатовский В.И., Казаченко А.В., Плотников Е.Ю., Марей М.В. и др. // Экспериментальная и клиническая урология. – 2011. - № 2-3. – С.33 – 39.

Меркулов Г.А. Курс патогистологической техники / Меркулов Г.А. – М.: Медгиз, 1961. – 341 с.

Murugan R. Acute kidney injury: what's the prognosis? / Murugan R., Kellum J.A. // Nat Rev Nephrol. – 2011. – V. 7. – P. 209-217.

Chawla L.S. The severity of acute kidney injury predicts progression to chronic kidney disease / Chawla L.S., Amdur R.L., Amodeo S., et al. // Kidney Int. – 2011. – Vol.79. – P. 1361-1369.


Abstract views: 319
PDF Downloads: 210
Published
2017-12-12
How to Cite
Kondakov, I. I., Topchii, I. I., & Kirienko, O. M. (2017). INFLUENCE OF GLICEROL ON FUNCTIONAL-MORPHOLOGICAL INDICATORS OF KIDNEYS AT MODELLING RENAL INSUFFICIENCY IN RATS. Ukrainian Journal of Nephrology and Dialysis, (3(39), 14-20. https://doi.org/10.31450/ukrjnd.3(39).2013.02