Hemoglobinuria and acute kidney injury in severe malaria: Case reports from Borgou/Alibori Teaching Hospital, Benin

Seraphin Ahoui; Nonvignon Éric  Ayadji; Giovanna Zossoungbo; Joseph Godonou; Aubin  Melikan; Aimé  Vinasse; Sabrina Conchita  Somakou; Nicanor  Houeto; Evariste  Eteka; Jacques  Vigan

doi:10.31450/ukrjnd.4(84).2024.03

Seraphin Ahoui Department of Nephrology, Faculty of Medicine, University of Parakou, Benin http://orcid.org/0000-0002-4949-0501
Nonvignon Éric Ayadji Department of Nephrology, Faculty of Health Sciences, University of Abomey-Calavi, Benin https://orcid.org/0009-0004-4885-5857
Giovanna Zossoungbo Department of Nephrology, Faculty of Health Sciences, University of Abomey-Calavi, Benin https://orcid.org/0009-0004-2938-0331
Joseph Godonou Department of Nephrology, Faculty of Medicine, University of Parakou, Benin http://orcid.org/0009-0008-2692-1138
Aubin Melikan Department of Nephrology, Faculty of Medicine, University of Parakou, Benin http://orcid.org/0009-0008-8367-1489
Aimé Vinasse Department of Nephrology, Faculty of Medicine, University of Parakou, Benin https://orcid.org/0009-0008-5013-752X
Sabrina Conchita Somakou Department of Nephrology, Faculty of Health Sciences, University of Abomey-Calavi, Benin https://orcid.org/0009-0003-0347-3583
Nicanor Houeto Department of Nephrology, Faculty of Medicine, University of Parakou, Benin http://orcid.org/0009-0008-1003-3849
Evariste Eteka Department of Nephrology, Faculty of Medicine, University of Parakou, Benin http://orcid.org/0009-0009-8083-610X
Jacques Vigan National Institute of Health, Medicine, University of Abomey-Calavi, Benin http://orcid.org/0000-0003-1375-0022

DOI: https://doi.org/10.31450/ukrjnd.4(84).2024.03

Keywords: acute kidney injury, hemoglobinuria, severe malaria, Benin.

Abstract

The hemoglobinuric form of severe malaria can precipitate acute kidney injury (AKI) and potential multiorgan failure. This report discusses two cases of fatal AKI due to severe malaria, treated in 2024 at the Borgou-Alibori Departmental Teaching Hospital in Benin. It examines the pathophysiology, clinical symptoms, and treatments used, providing detailed insights into the progression of the disease and the therapeutic interventions attempted. Key takeaways highlight the importance of early, multidisciplinary care in improving outcomes, with hemodialysis playing a critical role in managing AKI caused by hemoglobinuria.

Downloads

Download data is not yet available.

References

World Health Organization. Guidelines for treatment of malaria - 2nd edition - [Internet].2010. Available from: https://www.ncbi.nlm.nih.gov/books/NBK254223/.

Esezobor CI, Ladapo TA, Osinaike B, Lesi FE. Paediatric acute kidney injury in a tertiary hospital in Nigeria: prevalence, causes and mortality rate. PloS One. 2012;7(12):e51229. doi: 10.1371/journal.pone.0051229.

Kunuanunua TS, Nsibu CN, Gini-Ehungu JL, Bodi JM, Ekulu PM, Situakibanza H, et al. Acute kidney failure and severe malaria in Congolese children living in Kinshasa, Democratic Republic of Congo. Nephrol Ther.2013;9:160-65. doi: 10.1016/j.nephro.2013.01.001.

Kaul A, Sharma RK, Tripathi R, Suresh KJ, Bhatt S, Prasad N. Spectrum of community-acquired acute kidney injury in India : a retrospective study. Saudi J Kidney Dis Transpl. [Internet].2012;23:619-28. Available from: https://pubmed.ncbi.nlm.nih.gov/22569459/.

Kissou SA, Cessouma R, Barro M, Traoré H, Nacro B. Acute renal failure and Plasmodium falciparum malaria: a case report. Arch Pediatr. 2012;19(1):34-7. doi: 10.1016/j.arcped.2011.10.007.

Ponte B, Saudan P. Acute renal failure in 2008. Rev Med Switzerland. [Internet].2008;4(147):568-75. Available from: https://pubmed.ncbi.nlm.nih.gov/18402014/./a>

Lebas C, Vilaine E, Lessore De Sainte Foy C, Lemaitre L, Verine J, Buob D, et al. Renal damage revealing paroxysmal nocturnal hemoglobinuria: report of three cases. Nephrology Therapeutic. 2015;11(5):372.

Bruneel F, Gachot B, Wolff M, Bedos JP, Regnier B, Danis M, et al. Blackwater fever. Press Med. [Internet].2002;31(28):1329-34. Available from: https://pubmed.ncbi.nlm.nih.gov/12355996/.

Ajetunmobi WA, Orimadegun AE, Brown BJ, Afolabi NK, Olabiyi FA, Anetor JI, et al. Haemoglobinuria among children with severe malaria attending tertiary care in Ibadan, Nigeria. Malaria Journal.2012;11:336. doi: 10.1186/1475-2875-11-336.

Gbadoé AD, Kini-Caussi M, Koffi S, Traoré H, Atakouma DY, Tatagan-Agbi K, et al. Evolution of severe pediatric malaria in Togo between 2000 and 2002. Med Mal Infect. 2006;36(1):52-4. doi: 10.1016/j.medmal.2005.10.006.

World Health Organization. A multicentre study in the African Region. WHO Regional Office for Africa; 2002. Clinical, behavioural and socioeconomic factors related to severe malaria.

Verma P, Shukla US, Kalraiya A. Retrospective study on clinical profile of severe malaria in children admitted in a tertiary care centre of Central India. People’s Journal of Scientific Research. [Internet].2014;7(1):22–6. Available from: https://pjsr.org/WebPages/ArchivesPages/Vol7-1-2014Abs/5.pdf.

Newbold C, Craig A, Kyes S, Rowe A, FernandezReyes D, Fagan T. Cytoadherence, pathogenesis and the infected red cell surface in Plasmodium falciparum. Int J Parasitol.1999;29 (6):927-37. doi: 10.1016/s0020-7519(99)00049-1.

Kaushik RL, Kaushik RM, Kakkar R, Shamar A,Chandra H. Plasmodium vivax malaria complicated by acute kidney injury : experience at a referral hospital in Uttarakhand, India. Tran R Soc Med Hyg.2013;107:188-94. doi: 10.1093/trstmh/trs092.

Lalya F, Sagbo G, Bagnan- Tossa L, Alihonou F, Tohodjede Y, Almeida M, et al. Renal insufficiency associated with malaria in children at the CNHU Hubert K. Maga (CNHU-HK) in Cotonou, Benin. Rev Afr Anesth Med Urg. [Internet].2014; 19 (1): 39-43. Available from: https://bec.uac.bj/uploads/publication/33ffe4a584d0d9aa11b65c041e1c6ba4.pdf.

Kochar DK, Tanwar GS, Khatri PC, Kochar SK, Sengar GS, Gupta A, et al. Clinical characteristics of children hospitalized with malaria: a study from bikaner North-West India. J Trop Med Hyg.2010;83(5):981-9. doi: 10.4269/ajtmh.2010.09-0633.

Tondi ZMM, Nayama M, Kane Y, Garba M, Lemrabott AT, Moussa HD, et al. Acute Obstetric Renal Failure: Experience of the Issaka GAZOBY Maternity Hospital in Niamey (Niger). Eur Sci J. 2016;12(33):281. doi: 10.19044/esj.2016.v12n33p281.

Mabiala-Babela JR, Kaly-Ibala R, Ganga- Zandzou PS, Mouko A, Senga P. Severe malaria associated with acute renal failure: about an observation. Bull Soc Pathol Exote. [Internet].2002; 95 (2): 74-75. Available from: https://pubmed.ncbi.nlm.nih.gov/12145961/.

Essola L, Mowangue PS, Minko J, Ngomas JF, Soami V, Sima Zué A. Management of Acute Renal Failure in Severe Malaria in Children at the Libreville University Hospital Center. A Study of 12 Cases Health Sci Dis. 2019; 20 (4): 57-61.