VASOMOTOR FUNCTION OF THE ENDOTHELIUM IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HYPERTENSION
Анотація
Investigation of the functional state of the vascular endothelium contributes to the further study of the mechanisms of development and pharmacological correction, particularly in hypertensive patients with chronic kidney disease.
Material and Results. The study involved 172 patients with arterial hypertension (AH) in patients with chronic kidney disease. In the study of vascular-motor response to decompression and test with nitroglycerin in 60% of cases occur reduced vasodilatory and in 12.6% constrictor response. Normal character of vasodilation was 27.4%. Endothelium-independent vasodilation in the brachial artery decompression was reduced by 51.1% compared with the control. The growth of endothelium-independent vasoconstriction in the degree III AH was reduced to a lesser degree than the endothelium dependent - by 6.5% and 19.4% (p<0.01), respectively.
Conclusion. Thus impaired endothelium-mediated autoregulation of vascular tone in hypertensive patients with chronic kidney disease is an important element in the pathogenesis of high blood pressure as one of major adaptation mechanisms.
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Посилання
Драпкина О. М. Коррекция эндотелиальной дисфункции: акцент на липидоснижающую терапию / О. М. Драпкина, О. Н. Дикур // Болезни сердца и сосудов. – 2010. – № 1. – С. 49-53.
Колесник М. О. Медико-профілактична допомога хворим нефрологічного профілю в Україні / М. О. Колесник, Н. О. Сайдакова, Н. І. Козлюк // Український журнал нефрології та діалізу. - 2011. - № 4 (32). – С. 3-11.
Сапатий А.Л. Метаболічні особливості оксиду азоту у формуванні ендотеліальної дисфункції за серцево-судинних захворювань / А.Л.Сапатий, І. Г. Купновицька // Ліки України. – 2008. - №6. – С. 82-86.
Appleton C. Doppler assessment of left ventricular diastolic function: the refinements continue / C. Appleton // J. Am. Coll. Cardiol. – 1993. – № 21. – P. 1697–1700.
Coll B. Cardiovascular risk factors underestimate atherosclerotic burden in chronic kidney disease: usefulness of non-invasive tests in cardiovascular assessment / B. Coll, A. Betriu, M. Martinez-Alonso [et al.] // Nephrol. Dial. Transplant. – 2010. – Vol. 20. – P. 3017–3025.
Corretti M. C. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilatation of the brachial artery : a report of the international Brachial Artery Reactivity Task Force / М. С. Corretti, T. J. Anderson, T. J. Benjamin [et al.] // J. Amer. Coll. Cardiol. - 2002. - Vol.66. - P.529-565.
Ha J. W. Therapeutic strategies for diastolic dysfunction: a clinical perspective / J. W. Ha, J. K. Oh // J. Cardiovasc. Ultrasound. – 2009. – Vol. 17, N 3. – P. 86-95.
Sciacqua A. Endothelial dysfunction and non-alcoholic liver steatosis in hypertensive patients / A. Sciacqua, M. Perticone, S. Miceli [et al.] // Nutr. Metab. Cardiovasc. Dis. – 2010. - Mar 11.
Shah R. V. The effect of renin-angiotensin system inhibitors on mortality and heart failure hospitalization in patients with heart failure and preserved ejection fraction: a systematic review and meta-analysis / R. V. Shah, A. S. Desai, M. M. Givertz [et al.] // J. Card. Fail. – 2010. – Vol. 16, N 3. – P. 260-267.
Zucker I. H. Neurohumoral stimulation / I. H. Zucker, K. P. Patel, H. D. Schultz // Heart Fail. Clin. – 2012. – Vol. 8, N 1. – P. 87-99.
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