Effect of classic soft drink Coca-Cola as a solvent in the administration of tramadol and diazepam on biochemical and histological changes in liver and kidney

Omotayo B.  Ilesanmi; Temitope T.  Odewale

doi:10.31450/ukrjnd.3(67).2020.06

Omotayo B. Ilesanmi Федеральний університет Отуоке https://orcid.org/0000-0003-4074-2239
Temitope T. Odewale Університет Беніну

DOI: https://doi.org/10.31450/ukrjnd.3(67).2020.06

Ключові слова: гепатотоксичність, нефротоксичність, гістологія, трамадол, діазепам, Coca-Cola.

Анотація

Метою цього дослідження було визначити біохімічні та морфологічні зміни в печінці та нирках внаслідок введення трамадолу та діазепаму разом з класичним безалкогольним напоєм Coca-Cola.

Методи. Тридцять шість (36) дорослих самців щурів Вістар були розподілені на шість груп: група А-контроль (дистильована вода), група В (Coca-Cola), група С (трамадол, 50 мг/кг), група D (трамадол, розчинений у Coca-Cola, 50 мг/кг), група Е (діазепам, 10 мг/кг) та група F (діазепам, розчинений у Coca-Cola 10 мг/кг). Розчини вводили внутрішньочеревно. Через двадцять чотири години після введення, за допомогою пункції серця, забирали зразки крові для оцінки функції печінки (аспартатамінотрансферази [AST] та аланінамінотрансферази [ALT]), нирок (сечовини та креатиніну [Cr]). а органи були висічені та оброблені для гістопатологічного дослідження.

Результати. Введення розчину трамадолу з Coca-Cola значно збільшувало активність AST, концентрації Cr та сечовини порівняно з контрольною групою (P <0,05), тоді як діазепам не мав значного впливу на AST, ALT (P > 0,05), але призводив до значного збільшення сечовини та Cr (P < 0,05). Розчинення трамадолу в Coca-Cola посилювало його гепато- та нефротоксичність, тоді як Coca-Cola не мала значного впливу на діазепам. Гістологічне дослідження також підтвердило результати аналізу біохімічних даних.

Висновки. Змішування наркотиків з Coca-Cola не зменшує токсичність трамадолу та не має істотного впливу на діазепам.

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Вплив класичного безалкогольного напою Кока-Коли як розчинника при введенні трамадолу та діазепаму на біохімічні та гістологічні зміни печінки та нирок

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