Вплив омега-3 жирної кислоти на контраст-індуковану нефропатію

DOI: https://doi.org/10.31450/ukrjnd.4(72).2021.03
Ключові слова: контраст-індукована нефропатія, експериментальні тварини, омега-3 жирна кислота.

Анотація

Резюме. Контраст-індукована нефропатія (КІН) має високий ризик захворюваності та смертності. Метою цього дослідження було продемонструвати терапевтичний вплив омега-3 жирних кислот на КІН, беручи до уваги переваги омега-3 жирних кислот.

Методи. До дослідження залучено 30 щурів, розділених на чотири групи. Групі 1 за допомогою зонда вводили фізіологічний розчин, групі 2 довенно вводили контрастну речовину, групі 3 – лише 400 мг омега-3, а групі 4 – контрастну речовину та 400 мг омега-3. Наприкінці експериментального дослідження аналіщували тканину нирок та сироватку крові щодо концентрації оксидативних й антиоксидантних маркерів та рівня креатиніну.

Результати. У той час як показники глутатіонпероксидази, каталази та загальної антиоксидантної здатності в нирковій тканині та сироватки щурів, які отримували омега-3 жирні кислоти, зросли статистично, загальна окислювальна здатність і рівні малонового діальдегіду значно знижувались. Крім того, було виявлено, що рівні азоту сечовини крові та креатиніну були значно нижчими в групі, яка отримувала омега-3.

Висновок. Омега-3 мала терапевтичний ефект у експериментальній моделі КІН. Ми вважаємо, що омега-3 жирні кислоти можна використовувати як альтернативу існуючим підтримуючим засобам лікування.

Завантаження

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Посилання

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Опубліковано
2021-09-15
Як цитувати
Bolatli, G., Ulusoy, M., Tas, F., Alayunt, N. O., & Zarasiz, I. (2021). Вплив омега-3 жирної кислоти на контраст-індуковану нефропатію. Український Журнал Нефрології та Діалізу, (4(72), 15-25. https://doi.org/10.31450/ukrjnd.4(72).2021.03
Номер
№ 4(72) (2021): Ukrainian Journal of Nephrology and Dialysis
Розділ
Оригінальні наукові роботи
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