ROLE OF CELL HYPOXIA IN CHRONIC GLOMERULONEPHRITIS PROGRESSION IN CHILDREN

  • V. G. Maidannyk
  • E. A. Burlaka
  • I. V. Bagdasarova
  • S. P. Fomina

Abstract

Indicators of chronic inflammation, cellular hypoxia and apoptosis were studied in 48 nephrotic children. It was found that the disease course is accompanied by increased speed of superoxide radical-anions generation by neutrophilic granulocytes, increased levels of hypoxia-induced factor HIF-1α and decreased expression of antiapoptotic factor Bcl-xL. Detected changes significantly depended on the degree of proteinuria and declining of glomerular filtration rate. Utility of studied parameters was proved as predictors of unfavorable disease course. The mechanism of progression of hypoxia-induced renal damage in children with nephrotic syndrome was presented.

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Published
2017-12-12
How to Cite
Maidannyk, V. G., Burlaka, E. A., Bagdasarova, I. V., & Fomina, S. P. (2017). ROLE OF CELL HYPOXIA IN CHRONIC GLOMERULONEPHRITIS PROGRESSION IN CHILDREN. Ukrainian Journal of Nephrology and Dialysis, (1(33), 58-62. https://doi.org/10.31450/01-10

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